What's cost basis?
Simply put, cost basis is the amount you paid—including brokerage fees, loads, and any other trading costs—to purchase an investment. This often means the price at the time of original purchase, although in some cases you'll have an adjusted cost basis.
Any time you sell an investment, you'll look at the difference between the current market value and your cost basis to determine whether you've had a gain or a loss on the sale. That's something to consider as you think about your overall tax strategy.
You'll also want to factor in the amount of time you've held an investment, since an asset you've held for over a year is considered a long-term investment and could be taxed at a lower rate than a short-term investment (something owned for less than 1 year).